Description

Melittin CAS NO 37231-28-0 is the principal active peptide component of honey bee (*Apis mellifera*) venom. This amphipathic, 26-amino acid peptide is of significant commercial and research interest due to its potent hemolytic and cytolytic properties. It serves as a critical raw material and research tool for pharmaceutical development, biotechnology, and life science research, particularly in studies of membrane interactions, antimicrobial agents, and cancer therapeutics.

Application

• Pharmaceutical Research & Drug Discovery: Used as a model compound for studying peptide-membrane interactions, pore formation, and the development of novel antimicrobial and anticancer agents.
• Biotechnology & Life Science Reagents: A key component in cell lysis buffers, cytotoxicity assays, and as a standard in biochemical research to induce controlled membrane permeabilization.
• Venom Research & Toxicology: Essential for studying the mechanisms of honey bee venom toxicity, developing antivenoms, and conducting safety assessments.
• Cosmeceutical Research: Investigated for potential applications in topical formulations targeting microbial skin conditions, though primarily at the R&D stage.
• Academic & Industrial R&D: Serves as a high-purity reference standard in analytical laboratories for method development and quality control of venom-derived products.

Basic Information

Product Name	Melittin
CAS No.	37231-28-0
Molecular Formula	C₁₃₁H₂₂₉N₃₉O₃₁
Molecular Weight	2846.46 g/mol
Synonyms	Melittin; Apis mellifera melittin; Bee Venom Peptide; Melittin (Honey Bee); 26-L-Lysine-27-L-arginine-melittin; MFCD00132630; NSC 106977; UNII-20449-79-0; Honeybee Venom Basic Protein
EINECS	Contact for details

Quality Control

Our Melittin is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity (Hemolysis Assay)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.