Description

α-Hydroxyalprazolam is a key pharmaceutical intermediate and metabolite of the benzodiazepine class. This compound is critical for research and development in analytical chemistry and forensic toxicology, providing a reference standard for metabolite identification and quantification. It is primarily utilized by pharmaceutical R&D laboratories, forensic science institutions, and contract research organizations (CROs) for method development and quality control.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of alprazolam metabolites in pharmacokinetic and bioequivalence studies.
• Forensic Toxicology: Used as an analytical standard in urine drug testing and post-mortem analyses to confirm the presence of alprazolam and its metabolites.
• Metabolite Research: Essential for studying the metabolic pathways, stability, and clearance of alprazolam in clinical and pre-clinical research.
• Method Development & Validation: A critical component for developing and validating sensitive analytical methods such as LC-MS/MS, GC-MS, and HPLC in compliance with regulatory guidelines.
• Quality Control (QC) Testing: Employed by pharmaceutical manufacturers to ensure the purity and consistency of alprazolam-based drug products and to monitor for specific impurities.

Basic Information

Product Name	α-Hydroxyalprazolam
CAS No.	37115-43-8
Molecular Formula	C17H13ClN4O
Molecular Weight	324.76 g/mol
Synonyms	α-Hydroxyalprazolam; 8-Chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-ol; Alprazolam Metabolite; Alprazolam Impurity; 1-Methyl-8-chloro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepin-4-ol
EINECS	Contact for details

Quality Control

Every batch of α-Hydroxyalprazolam is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to support its use as a reference material. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity (by IR and MS), and related substances. Our quality protocols are designed to meet the exacting standards required for pharmaceutical research and forensic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.