Description

5-(2-Methylsulfonyloxyethyl)-Uracil is a specialized uracil derivative, a key synthetic intermediate in the development of novel nucleoside analogs and pharmaceutical compounds. This compound is valued for its reactive mesylate group, which facilitates selective alkylation and conjugation reactions in complex organic syntheses. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of antiviral agents, anticancer drugs, and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Bioconjugation Chemistry: Used to introduce uracil moieties into larger biomolecules, peptides, or polymers via its reactive sulfonate ester group.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Nucleic Acid Chemistry: Employed in the preparation of modified nucleosides and nucleotides for biochemical and biophysical studies.
• Chemical Biology Probes: Utilized to create labeled or tagged uracil derivatives for investigating biological processes.

Basic Information

Product Name	5-(2-Methylsulfonyloxyethyl)-Uracil
CAS No.	37107-76-9
Molecular Formula	C8H12N2O5S
Molecular Weight	248.26 g/mol
Synonyms	5-(2-Methanesulfonyloxyethyl)uracil; 5-[2-(Methylsulfonyloxy)ethyl]uracil; Uracil, 5-(2-((methylsulfonyl)oxy)ethyl)-; 5-(2-Hydroxyethyl)uracil methanesulfonate (ester); 5-(2-Mesyloxyethyl)uracil; 5-(2-Methylsulfonatoethyl)uracil; 37107-76-9 (CAS)
EINECS	Contact for details

Quality Control

Our 5-(2-Methylsulfonyloxyethyl)-Uracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.