Description

Proline, 1-Hydroxy- is a non-proteinogenic amino acid derivative, specifically a hydroxylated analog of proline. This compound is significant as a versatile chiral building block and intermediate in organic synthesis and pharmaceutical research. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and antibiotic research.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and metabolic pathway analysis.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships and modify peptide stability.
• Agrochemical Development: Serves as a precursor for designing new herbicides and plant growth regulators with specific chiral activity.
• Cosmetic Ingredients: Potential intermediate in the synthesis of certain moisturizing or anti-aging compounds.
• Catalyst Ligand: Can be utilized in the development of chiral ligands for asymmetric catalysis.

Basic Information

Product Name	Proline, 1-Hydroxy-
CAS No.	36901-87-8
Molecular Formula	C₅H₉NO₃
Molecular Weight	131.13 g/mol
Synonyms	1-Hydroxyproline; (2S)-1-Hydroxypyrrolidine-2-carboxylic Acid; L-1-Hydroxyproline; Hydroxyproline (isomer); 1-Hydroxy-L-proline; 1-Hydroxy-2-pyrrolidinecarboxylic Acid; Oxoproline (related); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Proline, 1-Hydroxy- is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters such as assay, chiral purity, and impurity profiles. Specifications can be aligned with research or cGMP requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.