Description

Gentamicin B1 CAS NO 36889-16-4 is a specific, high-purity component of the Gentamicin complex, a well-established class of aminoglycoside antibiotics. This compound is critical for research, analytical reference, and the development of specialized pharmaceutical formulations where precise composition and activity are paramount. It is primarily required by pharmaceutical R&D laboratories, quality control departments, and manufacturers of antibiotic reference standards and intermediates.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the identification, assay, and impurity profiling of Gentamicin sulfate bulk drugs and finished products.
• Research & Development: Used in microbiological and biochemical studies to investigate the structure-activity relationships (SAR) of aminoglycoside antibiotics and their mechanisms of action.
• Analytical Chemistry: Employed as a critical component in developing and validating high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) methods for antibiotic analysis.
• Impurity Standard: Acts as a known impurity or related substance standard for quality control testing, ensuring compliance with pharmacopeial monographs (USP, EP, BP).
• Intermediate Synthesis: Utilized as a key intermediate or starting material in the synthesis of novel antibiotic derivatives or labeled compounds for tracer studies.

Basic Information

Product Name	Gentamicin B1
CAS No.	36889-16-4
Molecular Formula	C20H41N5O7
Molecular Weight	463.57 g/mol
Synonyms	Gentamicin B1; Gentamicin B1; Gentamicin C1b; 2-Deoxygaramine; O-3-Deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine; Antibiotic G 418 component B1; Sch 9724 component B1
EINECS	Contact for details

Quality Control

Our Gentamicin B1 is produced and tested under strict quality management systems. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency, meeting the requirements for research and reference standard applications. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological purity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Water Content (KF)	≤ 5.0% w/w
Residual Solvents (GC)	Complies with ICH guidelines
Microbial Enumeration	Complies with USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.