Description

Poly(Glu(56)-Lys(35)-Phe(9))N CAS NO 36877-42-6 is a synthetic, amphoteric polypeptide composed of specific molar ratios of glutamic acid, lysine, and phenylalanine residues. This engineered polymer is valued for its unique combination of cationic and anionic functionalities, enabling precise control over surface charge and interaction with biological systems. It is primarily utilized by researchers and formulators in the pharmaceutical and biomedical sectors for advanced drug delivery, tissue engineering, and as a model compound for studying polyelectrolyte behavior.

Application

• Drug Delivery Systems: As a biodegradable and biocompatible carrier for controlled release of therapeutic agents, leveraging its tunable charge density.
• Biomedical Research: A model polyelectrolyte for fundamental studies on protein-polymer interactions, cell adhesion, and biomaterial surface modification.
• Tissue Engineering Scaffolds: Component in hydrogel or film formulations designed to support cell growth and tissue regeneration.
• Gene Delivery: Potential use as a non-viral vector for complexing and delivering nucleic acids, facilitated by its cationic lysine segments.
• Cosmetic Formulations: As a film-forming or conditioning agent in high-performance skincare products due to its polypeptide nature.
• Advanced Material Science: Building block for creating smart materials with pH-responsive or self-assembling properties.

Basic Information

Product Name	Poly(Glu(56)-Lys(35)-Phe(9))N
CAS No.	36877-42-6
Molecular Formula	(C5H7NO3)56·(C6H12N2O)35·(C9H9NO)9 (Monomer Basis)
Molecular Weight	Variable (Polymer)
Synonyms	Poly(Glutamic Acid(56)-Lysine(35)-Phenylalanine(9)) Amide; Poly(Glu-Lys-Phe) (56:35:9); PLG Copolymer (56:35:9); Poly(GL) Copolymer; Synthetic Amphoteric Polypeptide; Poly(glutamic acid-co-lysine-co-phenylalanine); EKL Copolymer; Poly(E,K,L)
EINECS	Contact for details

Quality Control

Our Poly(Glu(56)-Lys(35)-Phe(9))N is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure consistency in amino acid composition, molecular weight distribution, and purity. Certificates of Analysis (COA) detailing specifications for assay, residual solvents, and endotoxin levels are available upon request, supporting applications in research and GMP-guided development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry, inert conditions to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Amino Acid Ratio (Glu:Lys:Phe)	~56:35:9
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Endotoxin (LAL)	< 10 EU/mg (if required)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.