Description

α-Methyldethiobiotin is a key synthetic intermediate and structural analog of biotin, a vital B-complex vitamin. This compound is of significant value in biochemical research and pharmaceutical development due to its role in studying biotin-dependent enzymes and metabolic pathways. It is primarily utilized by researchers and manufacturers in the life sciences, pharmaceutical, and fine chemical sectors for applications ranging from enzyme inhibition studies to the synthesis of novel bioactive molecules.

Application

• Biochemical Research: Used as a tool compound to investigate the mechanism and inhibition of biotin-dependent carboxylases, such as acetyl-CoA carboxylase and pyruvate carboxylase.
• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of novel drug candidates targeting metabolic disorders and cancers linked to biotin metabolism.
• Enzyme Studies: Acts as a substrate analog in enzymatic assays to study binding affinity, kinetics, and the catalytic function of avidin, streptavidin, and related proteins.
• Nutritional Science Research: Employed in studies exploring biotin analogs and their effects on cellular metabolism and vitamin function.
• Diagnostic Reagent Development: Potential use in the formulation of assay kits and diagnostic tools that leverage the high-affinity biotin-streptavidin interaction system.
• Fine Chemical Synthesis: A versatile chiral synthon for the preparation of more complex, functionally modified biotin derivatives for specialized applications.

Basic Information

Product Name	α-Methyldethiobiotin
CAS No.	36846-64-7
Molecular Formula	C11H20N2O3
Molecular Weight	228.29 g/mol
Synonyms	Dethiobiotin Methyl Ether; (+)-α-Methyldethiobiotin; (3aS,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric Acid Methyl Ester (dethio analog); 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic Acid Methyl Ester (dethio); Biotin Methyl Ether (dethio analog); α-Methyl-dethiobiotin
EINECS	Contact for details

Quality Control

Our α-Methyldethiobiotin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS) to ensure structural integrity and consistent high quality. Certificates of Analysis (COA) detailing all specifications are available upon request to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.