Description

2-Chloro-3,5-Difluoroaniline is a halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for precise structural modifications in target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a difluorinated aniline core.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the chloro and fluoro substituents enhance biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers and advanced organic materials.
• Dye and Pigment Industry: Intermediate for producing complex, high-performance dyes and pigments with specific color fastness and stability properties.
• Liquid Crystal & OLED Development: A valuable building block for creating fluorinated aromatic components used in electronic display materials.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to introduce aniline functionalities into complex molecular architectures.

Basic Information

Product Name	2-Chloro-3,5-Difluoroaniline
CAS No.	36556-60-2
Molecular Formula	C6H4ClF2N
Molecular Weight	163.55 g/mol
Synonyms	2-Chloro-3,5-difluoroaniline; 3,5-Difluoro-2-chloroaniline; 2-Chloro-3,5-difluorobenzenamine; Benzenamine, 2-chloro-3,5-difluoro-; 36556-60-2; 2-Chloro-3,5-difluoro-phenylamine; 2-Chloro-3,5-difluoroaniline (principal name)
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,5-Difluoroaniline is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, open flames, and strong oxidizing agents. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.