Description

2-Chloro-3,4-Difluoroaniline is a halogenated aniline derivative serving as a versatile and critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for the precise introduction of chloro and fluoro groups into target molecules, significantly altering their electronic properties and biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require high-purity intermediates for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro substituents enhance lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing aromatic compounds used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Dye & Pigment Manufacturing: Employed in the production of specialized, high-performance dyes and pigments that require halogenated aniline structures for color fastness and stability.
• Polymer & Resin Modifiers: Incorporated as a monomer or additive to impart specific properties like flame retardancy or chemical resistance to advanced polymers.
• Research & Development: Serves as a standard reagent in academic and industrial R&D labs for exploring new synthetic pathways and material science applications.

Basic Information

Product Name	2-Chloro-3,4-Difluoroaniline
CAS No.	36556-48-6
Molecular Formula	C6H4ClF2N
Molecular Weight	163.55 g/mol
Synonyms	3,4-Difluoro-2-chloroaniline; 2-Chloro-3,4-difluorobenzenamine; Benzenamine, 2-chloro-3,4-difluoro-; 2-Chloro-3,4-difluoro-phenylamine; 2-Chloro-3,4-difluoroaniline (principal name); 36556-48-6 (CAS Registry); 2-Cl-3,4-F2-C6H3NH2
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,4-Difluoroaniline is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including GC, HPLC, and NMR, to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents and acids. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant secondary packaging.

Specification

Item	Specification
Appearance	Light yellow to brown liquid or crystalline mass
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Purity (GC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.