Description

α-Methylhistamine Dihydrochloride CAS NO 36376-49-5 is a high-purity, dihydrochloride salt derivative of the histamine analog, α-methylhistamine. This compound is a critical pharmacological research tool and a key intermediate in the synthesis of advanced bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on neuroscience, immunology, and drug discovery programs.

Application

• Pharmacological Research: As a selective H3 receptor agonist for studying histamine receptor function and signaling pathways in neurological and inflammatory models.
• Reference Standard: Used as a certified analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control of related compounds.
• Chemical Synthesis: Serves as a vital building block and protected intermediate in the multi-step synthesis of novel histaminergic ligands and potential therapeutic agents.
• Biochemical Assays: Employed in in vitro enzyme assays and receptor binding studies to evaluate compound efficacy and selectivity.
• Academic Studies: Fundamental research into the role of the histaminergic system in sleep-wake regulation, cognitive function, and appetite control.

Basic Information

Product Name	α-Methylhistamine Dihydrochloride
CAS No.	36376-49-5
Molecular Formula	C6H13N3·2HCl
Molecular Weight	216.11 g/mol
Synonyms	α-Methylhistamine dihydrochloride; (S)-α-Methylhistamine dihydrochloride; 2-(1H-Imidazol-4-yl)-1-methyl-ethanamine dihydrochloride; 4(5)-(2-Aminopropyl)imidazole dihydrochloride; (S)-4-(2-Aminopropyl)imidazole dihydrochloride; HA-966 dihydrochloride (obsolete); NSC 403169
EINECS	Contact for details

Quality Control

Our α-Methylhistamine Dihydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.