Description

4-Methylhistamine Dihydrochloride is a high-purity, pharmacologically active histamine analog used extensively in research and development. This compound is critical for studying histamine H2 receptor activity and related biochemical pathways. It serves as a key intermediate and reference standard for pharmaceutical companies and research institutions focused on gastroenterology, immunology, and central nervous system disorders.

Application

• Pharmacological Research: A vital tool for in vitro and in vivo studies targeting histamine H2 receptors.
• Reference Standard: Used as a certified standard in analytical laboratories for method development and quality control of related pharmaceutical products.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) to identify and characterize new H2 receptor antagonists or agonists.
• Academic Research: Fundamental for university and institutional research into the role of histamine in gastric acid secretion, inflammation, and neuromodulation.
• Drug Discovery Intermediate: Serves as a synthetic building block in the development of novel therapeutic agents.

Basic Information

Product Name	4-Methylhistamine Dihydrochloride
CAS No.	36376-47-3
Molecular Formula	C6H13N3·2HCl
Molecular Weight	216.11 g/mol
Synonyms	4-Methylhistamine 2HCl; 2-(4-Methyl-1H-imidazol-5-yl)ethanamine dihydrochloride; 5-(2-Aminoethyl)-4-methylimidazole dihydrochloride; 4-Methylhistamine HCl; 4-MeHA·2HCl; SKF 91487; Histamine H2 Receptor Agonist
EINECS	Contact for details

Quality Control

Our 4-Methylhistamine Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.