Description

Ac-His-Ome is a protected derivative of the amino acid histidine, specifically the methyl ester of N-acetyl-L-histidine. This compound serves as a crucial building block and intermediate in advanced organic synthesis, particularly in the production of peptides and fine chemicals. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity, specialized amino acid derivatives for drug discovery and development.

Application

• Peptide Synthesis: A key protected intermediate for the solid-phase and solution-phase synthesis of complex peptides containing histidine residues.
• Pharmaceutical Research: Used in the development and manufacturing of active pharmaceutical ingredients (APIs) and novel therapeutic compounds.
• Bioconjugation: Serves as a precursor for creating labeled histidine derivatives used in biochemical assays and diagnostic tools.
• Chemical Biology: Employed in the study of enzyme mechanisms and protein-protein interactions where modified histidine is required.
• Fine Chemical Production: Acts as a chiral building block for the synthesis of non-peptide molecules with specific biological activity.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Ac-His-Ome
CAS No.	36097-48-0
Molecular Formula	C9H13N3O3
Molecular Weight	211.22 g/mol
Synonyms	N-Acetyl-L-histidine methyl ester; Ac-L-His-OMe; Nα-Acetyl-L-histidine methyl ester; L-Histidine, N-acetyl-, methyl ester; Methyl N-acetyl-L-histidinate; (2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoic acid methyl ester; Ac-His-OMe·HCl (hydrochloride salt form)
EINECS	Contact for details

Quality Control

Our Ac-His-Ome is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with your research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range available on COA
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.