Description

5-Oxoprolyltryptophan is a specialized dipeptide derivative, combining the pyroglutamic acid (5-oxoproline) and tryptophan moieties. This compound is of significant interest in biochemical research and pharmaceutical development due to its unique structural features. It serves as a valuable intermediate and reference standard for scientists in the fields of peptide chemistry, neurobiology, and metabolic pathway studies.

Application

• Biochemical Research: Used as a reference standard and intermediate in the study of peptide synthesis and modification.
• Pharmaceutical Development: Acts as a key building block or impurity standard in the synthesis of more complex peptide-based active pharmaceutical ingredients (APIs).
• Metabolic Studies: Investigated for its role in glutathione metabolism and related biochemical pathways involving 5-oxoproline.
• Neuroscience Research: Potential utility in studying neurotransmitter precursors and neuroactive peptides derived from tryptophan.
• Analytical Standard: Serves as a high-purity calibrant for analytical methods like HPLC and LC-MS in quality control laboratories.

Basic Information

Product Name	5-Oxoprolyltryptophan
CAS No.	35937-24-7
Molecular Formula	C16H17N3O5
Molecular Weight	331.32 g/mol
Synonyms	L-Pyroglutamyl-L-tryptophan; Pyrrolidonecarboxylyl-Tryptophan; 5-Oxo-L-prolyl-L-tryptophan; 5-Oxoprolyl-L-tryptophan; L-2-Pyrrolidone-5-carboxyl-L-tryptophan; PCA-Tryptophan; Pyroglutamyltryptophan; (S)-2-((S)-5-Oxo-2-pyrrolidinecarboxamido)-3-(1H-indol-3-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our 5-Oxoprolyltryptophan is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L,L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.