Description

Pglu-L-Phe-L-His-Nh2 CAS NO 35936-95-9 is a synthetic tripeptide derivative, specifically pyroglutamyl-L-phenylalanyl-L-histidinamide. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a precursor or intermediate in the synthesis of more complex peptides and potential bioactive molecules. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in peptide synthesis, drug discovery, and the study of enzyme-substrate interactions.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or building block in the synthesis of novel therapeutic peptides and peptidomimetics.
• Biochemical Studies: Used as a substrate or reference standard in enzymatic assays and studies of protease or peptidase activity.
• Peptide Library Synthesis: A valuable component in combinatorial chemistry for creating diverse peptide libraries for screening purposes.
• Academic Research: Employed in university and institutional labs for investigating peptide structure, function, and metabolism.
• Fine Chemical Synthesis: Acts as a specialized intermediate for custom peptide synthesis services and contract manufacturing organizations (CMOs).

Basic Information

Product Name	Pglu-L-Phe-L-His-Nh2
CAS No.	35936-95-9
Molecular Formula	C20H25N5O4
Molecular Weight	399.45 g/mol
Synonyms	Pyroglutamyl-L-phenylalanyl-L-histidinamide; L-Pyroglutamyl-L-phenylalanyl-L-histidinamide; pGlu-Phe-His-NH2; 5-Oxo-L-prolyl-L-phenylalanyl-L-histidinamide; TRH Precursor; Thyrotropin-Releasing Hormone Fragment; (S)-2-(2-((S)-2-Amino-3-phenylpropanamido)-3-(1H-imidazol-4-yl)propanamido)-5-oxopyrrolidine-1-carboxamide
EINECS	Contact for details

Quality Control

Our Pglu-L-Phe-L-His-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.