Description

3-Chloro-4-Hydroxybenzotrifluoride is a versatile fluorinated aromatic building block of significant commercial importance. Its unique structure, combining a phenolic hydroxyl group with a chloro and a trifluoromethyl substituent, makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients. This compound is primarily sought by R&D chemists and process engineers in the agrochemical, pharmaceutical, and specialty chemical industries for developing novel compounds with enhanced properties.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Pharmaceutical Building Block: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Liquid Crystal & OLED Material Synthesis: Serves as a starting material for creating fluorinated components in electronic display technologies and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart specific characteristics such as chemical resistance, thermal stability, or altered surface properties.
• Dye & Pigment Intermediate: Utilized in the production of advanced colorants and functional dyes where fluorine substitution is desirable.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures in medicinal chemistry.

Basic Information

Product Name	3-Chloro-4-Hydroxybenzotrifluoride
CAS No.	35852-58-5
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	4-Hydroxy-3-chlorobenzotrifluoride; 3-Chloro-4-hydroxy-α,α,α-trifluorotoluene; 2-Chloro-α,α,α-trifluoro-p-cresol; 1-Chloro-2-hydroxy-5-(trifluoromethyl)benzene; 3-Chloro-α,α,α-trifluoro-p-cresol; 3-Chloro-4-hydroxybenzene trifluoride; 3-Chloro-4-(trifluoromethyl)phenol; 3-Chloro-4-trifluoromethylphenol
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Hydroxybenzotrifluoride is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.