Description

5'-Acetyl-2'-O,3'-o-Benzylidene-5'-Deoxyuridine is a key protected nucleoside derivative, specifically a modified uridine, that serves as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its value lies in its role as a versatile building block for the synthesis of complex oligonucleotides, prodrugs, and novel antiviral or anticancer nucleoside analogs. This high-purity intermediate is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical synthesis companies focused on nucleotide-based therapeutics and diagnostics. The compound, with CAS No. 35837-31-1, is handled under controlled conditions to maintain its integrity for sensitive downstream applications.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the preparation of modified oligonucleotides for research, diagnostic probes, and therapeutic aptamers.
• Prodrug Development: Serves as a precursor for creating prodrug forms of nucleoside analogs to enhance bioavailability and targeting.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new bioactive nucleoside derivatives.
• Fine Chemical Synthesis: Acts as a specialized intermediate for custom synthesis and contract manufacturing organizations (CMOs).
• Bioconjugation: The protected and acetylated functionalities allow for selective chemical modifications and linker attachments.

Basic Information

Product Name	5'-Acetyl-2'-O,3'-o-Benzylidene-5'-Deoxyuridine
CAS No.	35837-31-1
Molecular Formula	C₁₈H₁₈N₂O₇
Molecular Weight	374.35 g/mol
Synonyms	5'-O-Acetyl-2',3'-O-benzylidene-5'-deoxyuridine; 2',3'-O-Benzylidene-5'-O-acetyl-5'-deoxyuridine; 5'-Deoxy-5'-acetyl-2',3'-O-benzylideneuridine; Uridine, 5'-deoxy-5'-acetyl-2',3'-O-(phenylmethylene)-; 5'-Acetyl-2',3'-O-benzylidene-5'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 5'-Acetyl-2'-O,3'-o-Benzylidene-5'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade specifications. Our quality commitment supports your need for reliable and consistent synthetic intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.