Description

Amino Acid Hydroxamates L-Arginine Hydroxamate Hydrochloride is a chemically modified derivative of the essential amino acid L-arginine, where the carboxyl group is converted to a hydroxamic acid functionality. This structural modification is critical for its role as a potent and selective inhibitor of metalloenzymes, particularly arginase, which is involved in key biological pathways. It is an essential research-grade biochemical for pharmaceutical R&D, life science studies, and the development of therapeutic agents targeting nitric oxide metabolism, immune regulation, and cardiovascular diseases.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel arginase inhibitors for treating conditions like hypertension, atherosclerosis, and certain cancers.
• Biochemical & Enzymology Studies: Used as a highly specific, competitive inhibitor in enzymatic assays to study the function and kinetics of arginase isoforms (ARG1 and ARG2) in various biological systems.
• Life Science & Cell Biology: A vital tool compound for modulating the urea cycle and nitric oxide (NO) synthesis pathways in cell culture models, helping to elucidate disease mechanisms related to immune function and vascular biology.
• Diagnostic Reagent Manufacturing: Employed in the formulation of specialized diagnostic kits and reagents designed to measure arginase activity in clinical and research laboratory settings.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes conducting studies in biochemistry, molecular biology, and medicinal chemistry focused on amino acid metabolism.

Basic Information

Product Name	Amino Acid Hydroxamates L-Arginine Hydroxamate Hydrochloride
CAS No.	35832-00-9
Molecular Formula	C6H15N5O2 • HCl
Molecular Weight	233.68 g/mol (Free base: 197.22 g/mol)
Synonyms	L-Argininehydroxamic acid hydrochloride; Arginine hydroxamate HCl; N5-(Aminoiminomethyl)-L-ornithine hydroxamic acid hydrochloride; (S)-2-Amino-5-(carbamimidamido)pentanohydroxamic acid hydrochloride; ArgHA•HCl; ARG-HA hydrochloride; NSC 134754; Arginase Inhibitor (hydroxamate form)
EINECS	Contact for details

Quality Control

Our L-Arginine Hydroxamate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.