Description

n-Cbz-L-Homoserine Lactone is a protected amino acid derivative widely used as a crucial chiral building block in advanced organic synthesis. This compound is essential for the controlled introduction of the homoserine lactone moiety, a key structural motif in various bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of protease inhibitors, peptide mimetics, and other complex therapeutic agents.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the synthesis of protease inhibitors, enzyme substrates, and other active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate the homoserine lactone structure into peptide chains.
• Chemical Biology Research: Serves as a precursor for synthesizing probes and inhibitors to study enzyme mechanisms and signal transduction pathways.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Natural Product Synthesis: A valuable intermediate in the total synthesis of complex natural products containing lactone or amino acid functionalities.

Basic Information

Product Name	n-Cbz-L-Homoserine Lactone
CAS No.	35677-89-5
Molecular Formula	C12H13NO5
Molecular Weight	251.24 g/mol
Synonyms	Carbobenzoxy-L-homoserine lactone; (S)-4-(Benzyloxycarbonylamino)-2-oxotetrahydrofuran; N-Carbobenzyloxy-L-homoserine lactone; N-Cbz-L-homoserine lactone; Cbz-Hse-lactone; (S)-4-((Benzyloxy)carbonylamino)dihydrofuran-2(3H)-one; Z-L-Homoserine lactone; Benzyl (S)-4-oxo-2-oxotetrahydrofuran-3-ylcarbamate
EINECS	Contact for details

Quality Control

Our n-Cbz-L-Homoserine Lactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.