Description

n-Carbobenzoxy-L-Homoserine CAS NO 35677-88-4 is a protected derivative of the non-proteinogenic amino acid L-homoserine, featuring a carbobenzoxy (Cbz) protecting group on the amine functionality. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and reactivity. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry, proteomics research, and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the solid-phase and solution-phase synthesis of bioactive peptides and constrained peptide analogs.
• Medicinal Chemistry Research: Used to incorporate the homoserine moiety into novel drug candidates, particularly in oncology and metabolic disease research.
• Proteomics & Biochemical Tools: Serves as a building block for synthesizing enzyme substrates, inhibitors, and activity-based probes to study protease function.
• Conjugation Chemistry: The protected amine and carboxylic acid groups allow for selective deprotection and subsequent conjugation to other molecules, scaffolds, or solid supports.
• Academic & R&D Laboratories: Employed in methodological development for peptide synthesis and as a standard in analytical chemistry for method validation.

Basic Information

Product Name	n-Carbobenzoxy-L-Homoserine
CAS No.	35677-88-4
Molecular Formula	C12H15NO5
Molecular Weight	253.25 g/mol
Synonyms	N-Cbz-L-Homoserine; (2S)-2-[[(Benzyloxy)carbonyl]amino]-4-hydroxybutanoic Acid; L-Homoserine, N-[(benzyloxy)carbonyl]-; CBZ-L-Homoserine; Z-L-Homoserine-OH; Benzyl N-[(2S)-2-carboxy-3-hydroxypropyl]carbamate; Nα-Carbobenzyloxy-L-homoserine
EINECS	Contact for details

Quality Control

Our n-Carbobenzoxy-L-Homoserine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for purity, chiral purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-Isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.