Description

1-Methyl-2-[(3R,5R)-3-Amino-5-Hydroxy-6-(L-Leucylamino)Hexanoyl]Hydrazinoacetic Acid is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate for the synthesis of complex bioactive molecules, particularly in the field of peptide-based therapeutics. It is essential for research chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries focused on creating novel drug candidates with specific stereochemical and functional properties.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and enzyme inhibitors.
• Peptide Synthesis: Used as a specialized building block in solid-phase and solution-phase peptide synthesis to introduce unique structural motifs.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies to probe biological pathways and mechanisms.

Basic Information

Product Name	1-Methyl-2-[(3R,5R)-3-Amino-5-Hydroxy-6-(L-Leucylamino)Hexanoyl]Hydrazinoacetic Acid
CAS No.	35663-84-4
Molecular Formula	C15H29N5O5
Molecular Weight	359.42 g/mol
Synonyms	N-[(3R,5R)-3-Amino-5-hydroxy-6-[(2S)-2-amino-4-methylpentanamido]hexanoyl]-N-methylglycine hydrazide; (3R,5R)-3-Amino-5-hydroxy-6-(L-leucylamino)-N-(1-methyl-2-oxo-2-hydrazinoethyl)hexanamide; L-Leucyl-(3R,5R)-3-amino-5-hydroxyhexanoyl-N-methylglycine hydrazide; AHHMHA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 1-Methyl-2-[(3R,5R)-3-Amino-5-Hydroxy-6-(L-Leucylamino)Hexanoyl]Hydrazinoacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.