Description

Glycine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical Fmoc-protected glycine building block, enabling the controlled and sequential assembly of complex peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptide hormones, and biochemical tools. The product is supplied with a guaranteed specification to ensure optimal coupling efficiency and yield in automated synthesis platforms.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-Gly-OH derivative, it is a fundamental reagent for the stepwise construction of peptide chains on resin supports.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a linker or spacer molecule in the synthesis of peptide-protein conjugates, antibody-drug conjugates (ADCs), and other bioconjugates.
• Combinatorial Chemistry: A key component in libraries for high-throughput screening to identify bioactive peptide leads.
• Biochemical Tool Development: Employed in the synthesis of substrates, inhibitors, and probes for enzymatic assays and diagnostic applications.
• Academic Research: Essential for studies in biochemistry, molecular biology, and medicinal chemistry involving custom peptide synthesis.

Basic Information

Product Name	Glycine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-, 1,1-Dimethylethyl Ester
CAS No.	35661-42-8
Molecular Formula	C21H23NO4
Molecular Weight	353.41 g/mol
Synonyms	Fmoc-Gly-OtBu; N-(9-Fluorenylmethoxycarbonyl)glycine tert-butyl ester; Fmoc-glycine tert-butyl ester; tert-Butyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycinate; Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1,1-dimethylethyl ester; N-Fmoc-glycine tert-butyl ester; Fmoc-Gly-OC(CH3)3
EINECS	Contact for details

Quality Control

Our Fmoc-protected amino acid derivatives are manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all test results are provided with every shipment. Our production adheres to cGMP principles where applicable, supporting their use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Specific Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.