Description

3,5-Diiodo-L-Tyrosine Ethyl Ester is a halogenated derivative of the amino acid L-tyrosine, specifically modified at the phenolic ring and the carboxylic acid group. This compound is a key synthetic intermediate in the production of thyroid hormone analogs and other bioactive molecules, offering a versatile building block for pharmaceutical research and development. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in endocrinology, radiopharmaceuticals, and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of thyroid hormone analogs like thyroxine (T4) and triiodothyronine (T3).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to tyrosine metabolism and thyroid function.
• Radiopharmaceutical Development: Serves as a starting material for the synthesis of iodine-123 or iodine-131 labeled compounds for diagnostic imaging or therapy.
• Organic Synthesis Building Block: Provides a diiodophenol moiety for constructing complex molecules in medicinal chemistry programs.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3,5-Diiodo-L-Tyrosine Ethyl Ester
CAS No.	35591-33-4
Molecular Formula	C11H13I2NO3
Molecular Weight	469.04 g/mol
Synonyms	L-Tyrosine, 3,5-diiodo-, ethyl ester; Ethyl 3,5-diiodo-L-tyrosinate; 3,5-Diiodotyrosine ethyl ester; DIET; (2S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid ethyl ester; Ethyl (2S)-2-amino-3-(4-hydroxy-3,5-diiodophenyl)propanoate; NSC 163039
EINECS	Contact for details

Quality Control

Our 3,5-Diiodo-L-Tyrosine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.