Description

4-Amino-2-Chloro-5-Nitrobenzotrifluoride is a versatile trifluoromethylated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring amino, chloro, nitro, and trifluoromethyl substituents, makes it a high-value intermediate for creating complex molecules with tailored properties. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and functional aromatic systems into their target compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Dye and Pigment Manufacturing: Intermediate for producing high-performance, light-fast azo dyes and organic pigments.
• Liquid Crystal and OLED Materials: Used in the synthesis of fluorinated aromatic components for electronic display materials.
• Polymer Chemistry: Monomer or modifier for creating specialty polymers with enhanced chemical resistance and thermal stability.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination, Suzuki coupling) for constructing complex biaryl structures.

Basic Information

Product Name	4-Amino-2-Chloro-5-Nitrobenzotrifluoride
CAS No.	35375-74-7
Molecular Formula	C7H4ClF3N2O2
Molecular Weight	240.57 g/mol
Synonyms	2-Chloro-4-amino-5-nitrobenzotrifluoride; 2-Chloro-4-amino-5-nitro-α,α,α-trifluorotoluene; 2-Chloro-α,α,α-trifluoro-4-amino-5-nitrotoluene; 5-Nitro-2-chloro-4-aminobenzotrifluoride; 4-Amino-2-chloro-5-nitro-α,α,α-trifluorotoluene; 1-Amino-4-chloro-2-nitro-5-(trifluoromethyl)benzene; Benzenamine, 4-chloro-2-nitro-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Amino-2-Chloro-5-Nitrobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider an inert atmosphere (e.g., nitrogen or argon) to maintain product integrity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.