Description

4-[[[5-(2-Methylpropyl)-2-Pyrimidinyl]Amino]Sulfonyl]-n-[(R)-1-Phenylethyl]Benzeneacetamide is a high-purity, chiral sulfonamide-based organic intermediate of significant interest in advanced pharmaceutical synthesis. Its precise stereochemistry and functional groups make it a valuable building block for creating targeted bioactive molecules. This compound is primarily utilized by research institutions and pharmaceutical development teams working on novel therapeutic agents, particularly in areas requiring specific receptor interaction or metabolic pathway modulation.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) or metabolic disorder targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its sulfonamide and pyrimidine motifs, which are common pharmacophores.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective synthesis to introduce the (R)-1-phenylethyl moiety into more complex molecular architectures.
• Biochemical Tool Compound: Potential use in biochemical assays as a probe or inhibitor to study specific enzyme or receptor functions in academic and industrial R&D settings.
• Process Chemistry Development: Acts as a critical intermediate during scale-up and process optimization for potential drug candidates under clinical evaluation.

Basic Information

Product Name	4-[[[5-(2-Methylpropyl)-2-Pyrimidinyl]Amino]Sulfonyl]-n-[(R)-1-Phenylethyl]Benzeneacetamide
CAS No.	35253-09-9
Molecular Formula	C24H28N4O3S
Molecular Weight	452.57 g/mol
Synonyms	N-[(1R)-1-Phenylethyl]-2-{4-[(5-isobutylpyrimidin-2-yl)sulfamoyl]phenyl}acetamide; (R)-N-(1-Phenylethyl)-2-(4-((5-isobutylpyrimidin-2-yl)sulfamoyl)phenyl)acetamide; 4-((5-Isobutylpyrimidin-2-yl)sulfamoyl)-N-((R)-1-phenylethyl)benzeneacetamide; UNII-7V2A2U0J4I; 7V2A2U0J4I; Benzeneacetamide, 4-(((5-(2-methylpropyl)-2-pyrimidinyl)amino)sulfonyl)-N-((1R)-1-phenylethyl)-
EINECS	Contact for details

Quality Control

Our 4-[[[5-(2-Methylpropyl)-2-Pyrimidinyl]Amino]Sulfonyl]-n-[(R)-1-Phenylethyl]Benzeneacetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet stringent specifications for research use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound may be light-sensitive and hygroscopic; handle and store under an inert atmosphere if long-term stability is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (R-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Any individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.