Description

5-Chloro-6-Methyl-3-(Tetrahydro-2H-Pyran-2-Yl)Uracil is a high-purity, advanced pharmaceutical intermediate characterized by its uracil core modified with chloro, methyl, and tetrahydropyranyl protecting groups. This compound matters as a critical building block in the synthesis of novel nucleoside analogs and antiviral agents, offering precise chemical functionality for targeted drug development. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in antiviral, anticancer, and other therapeutic research programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Serves as a core scaffold for developing compounds targeting viral polymerases and replication mechanisms.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Chemical Synthesis: Employed in organic synthesis for introducing protected uracil derivatives into more complex molecular architectures.
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.

Basic Information

Product Name	5-Chloro-6-Methyl-3-(Tetrahydro-2H-Pyran-2-Yl)Uracil
CAS No.	35252-87-0
Molecular Formula	C10H13ClN2O3
Molecular Weight	244.68 g/mol
Synonyms	5-Chloro-6-methyl-3-(tetrahydro-2H-pyran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5-Chloro-6-methyl-3-(tetrahydropyran-2-yl)uracil; 3-(Tetrahydro-2H-pyran-2-yl)-5-chloro-6-methyluracil; 5-Chloro-6-methyl-3-(oxan-2-yl)-1H-pyrimidine-2,4-dione; THP-Protected 5-Chloro-6-methyluracil; 35252-87-0; 5-Chloro-6-methyl-3-(2-tetrahydropyranyl)uracil
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-Methyl-3-(Tetrahydro-2H-Pyran-2-Yl)Uracil is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.