Description

Dethiophalloidin CAS NO 35173-40-1 is a specialized chemical compound belonging to the class of phallotoxins, which are cyclic peptides of fungal origin. This compound is of significant interest in biochemical and pharmacological research due to its specific interaction with actin filaments, making it a valuable tool for studying cytoskeletal dynamics and cellular processes. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in advanced cell biology studies, toxicology research, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a precise molecular probe for investigating actin polymerization, depolymerization, and the structure of microfilaments in vitro.
• Cell Biology Studies: Employed in fluorescence microscopy and other assays to visualize and quantify actin dynamics within living cells.
• Pharmacology & Toxicology: Serves as a reference standard or active agent in studies exploring the mechanisms of hepatotoxic compounds and potential antidotes.
• Drug Discovery: Utilized in high-throughput screening platforms to identify new compounds that modulate the cytoskeleton for potential therapeutic applications in cancer or other diseases.
• Academic Research: A key reagent for universities and research institutes focusing on structural biology, molecular modeling, and the fundamental principles of peptide-toxin interactions.

Basic Information

Item	Detail
Product Name	Dethiophalloidin
CAS No.	35173-40-1
Molecular Formula	C35H48N8O11S
Molecular Weight	788.87 g/mol
Synonyms	Dethiophalloidin; 7-De(thio-1-hydroxy-tryptophyl)phalloidin; Phalloidin, 7-de(thio-1-hydroxy-L-tryptophyl)-; NSC 334719; Phallotoxin derivative; Actin-binding probe; Cyclic heptapeptide toxin analog
EINECS	Contact for details

Quality Control

Our Dethiophalloidin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic identification (NMR, MS). Certificates of Analysis (COA) detailing all relevant specifications are provided to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.