Description

Z-Pro-Gly-Nh2 is a protected dipeptide building block, specifically the C-terminal amide derivative of the Z-protected Pro-Gly sequence. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure and function. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, particularly for developing protease inhibitors, neuropeptides, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected fragment for the sequential assembly of longer peptide chains.
• Pharmaceutical Research: Serves as a crucial intermediate in the development of novel therapeutic peptides targeting various diseases.
• Bioconjugation: Used to introduce specific peptide sequences into larger biomolecules or materials for functionalization.
• Chemical Biology Probes: Acts as a building block for creating labeled or modified peptides used to study biological pathways and enzyme activity.
• Library Synthesis: Employed in combinatorial chemistry to generate diverse peptide libraries for high-throughput screening.
• Academic Research: Fundamental tool for studying peptide structure-activity relationships (SAR) and conformation.

Basic Information

Product Name	Z-Pro-Gly-Nh2
CAS No.	35010-96-9
Molecular Formula	C16H21N3O5
Molecular Weight	335.36 g/mol
Synonyms	Z-Pro-Gly-NH2; N-[(Benzyloxy)carbonyl]-L-prolylglycinamide; CBZ-L-Prolyl-Glycinamide; N-Carbobenzoxy-L-prolylglycinamide; Nα-Cbz-L-Prolylglycinamide; Benzyloxycarbonyl-L-prolylglycinamide; Z-L-Prolyl-Glycinamide; L-Proline, N-[(phenylmethoxy)carbonyl]glycyl-, amide
EINECS	Contact for details

Quality Control

Our Z-Pro-Gly-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-Proline isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.