Description

Hypusine is a unique, naturally occurring amino acid derivative essential for the post-translational activation of the eukaryotic translation initiation factor 5A (eIF5A). This compound matters significantly in biochemical research for its critical role in cellular growth, proliferation, and apoptosis. It is primarily needed by research institutions, pharmaceutical developers, and biotechnology companies focused on aging, virology, and oncology studies. Hypusine CAS NO 34994-11-1 serves as a vital reference standard and a key biochemical tool for investigating hypusination pathways.

Application

• Biochemical Research Standard: Used as a high-purity reference material in analytical laboratories for method development and validation.
• Enzyme Substrate Studies: Serves as a substrate for deoxyhypusine synthase (DHPS) and deoxyhypusine hydroxylase (DOHH) in enzymatic activity assays.
• Cell Biology & Signal Transduction: Employed in studies to elucidate the role of eIF5A hypusination in cell cycle regulation, differentiation, and programmed cell death.
• Pharmaceutical R&D: Investigated as a potential target for therapeutic intervention in cancer, neurodegenerative diseases, and parasitic infections.
• Virology Research: Used to study the dependency of certain viruses, like HIV, on the host cell's hypusination pathway for replication.
• Nutritional Science: Analyzed in metabolic studies concerning amino acid metabolism and its potential dietary implications.

Basic Information

Product Name	Hypusine
CAS No.	34994-11-1
Molecular Formula	C9H21N3O3
Molecular Weight	219.28 g/mol
Synonyms	Nε-(4-Amino-2-hydroxybutyl)-L-lysine; (2S)-2-Amino-6-[(4S)-4-amino-2-hydroxybutylamino]hexanoic acid; L-Hypusine; Hypusine (free base); eIF5A precursor amino acid
EINECS	Contact for details

Quality Control

Our Hypusine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets high-grade research specifications. Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.