Description

(3S,4R)-3-Hydroxy-4-Methyl-L-Glutamic Acid CAS NO 34632-21-8 is a high-purity, non-proteinogenic amino acid derivative characterized by its specific stereochemistry at the 3 and 4 positions. This compound serves as a critical chiral building block and biochemical tool in advanced research and pharmaceutical development. It is essential for scientists and manufacturers in the fields of medicinal chemistry, peptide synthesis, and neuroscience research, where precise molecular structure and high enantiomeric purity are paramount for activity and study reproducibility.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, particularly in neurological and metabolic disorder research.
• Biochemical Research: Used as a reference standard and probe in enzymatic studies, receptor binding assays, and metabolic pathway analysis.
• Peptide Synthesis: Incorporated into custom peptides to study structure-activity relationships (SAR) and to create peptides with modified properties.
• Neuroscience Studies: Investigated for its potential role as an analog or modulator of glutamatergic signaling pathways.
• Process Development: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for complex molecules.

Basic Information

Product Name	(3S,4R)-3-Hydroxy-4-Methyl-L-Glutamic Acid
CAS No.	34632-21-8
Molecular Formula	C6H11NO5
Molecular Weight	177.16 g/mol
Synonyms	(2S,3S)-3-Hydroxy-4-methylglutamic acid; (3S,4R)-3-Hydroxy-4-methyl-L-glutamate; 3-Hydroxy-4-methyl-L-glutamic acid; HMGA; L-3-Hydroxy-4-methylglutamic acid; (2S,3S)-3-Hydroxy-4-methylpentanedioic acid 1-amide; 4-Methyl-3-hydroxy-L-glutamic acid
EINECS	Contact for details

Quality Control

Our (3S,4R)-3-Hydroxy-4-Methyl-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.