Description

2-Methylhistamine is a selective histamine H1 receptor agonist, a key chemical tool for pharmacological research and development. Its primary value lies in its ability to selectively activate H1 receptors, making it indispensable for studying histaminergic pathways, receptor function, and screening potential antagonists. This compound is essential for pharmaceutical companies, academic research institutions, and contract research organizations (CROs) focused on neuroscience, allergy, and inflammation research.

Application

• Pharmacological Research: As a selective H1 receptor agonist for in vitro and in vivo studies of histamine receptor signaling and function.
• Drug Discovery & Screening: A reference standard and tool compound for high-throughput screening (HTS) campaigns to identify novel H1 receptor antagonists and modulators.
• Neuroscience Studies: Investigating the role of the histaminergic system in sleep-wake cycles, appetite, learning, and memory.
• Allergy & Inflammation Models: Used to induce and study H1-mediated responses in cellular and animal models of allergic reactions and inflammatory processes.
• Biochemical Assay Development: Serving as a critical component in developing and validating functional assays for H1 receptor activity.
• Reference Standard: For analytical method development and quality control in the production of related pharmaceutical compounds.

Basic Information

Product Name	2-Methylhistamine
CAS No.	34392-54-6
Molecular Formula	C6H11N3
Molecular Weight	125.17 g/mol
Synonyms	2-Methylhistamine; 4-(2-Aminoethyl)-5-methyl-1H-imidazole; α-Methylhistamine; 2-Methyl-4-(2-aminoethyl)imidazole; 5-Methylhistamine; H1 receptor agonist; NSC 163045; 1H-Imidazole-4-ethanamine, 5-methyl-
EINECS	Contact for details

Quality Control

Our 2-Methylhistamine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Our commitment to quality and consistency supports reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.