Description

Arg-Gly-Phe-Phe-NH2 is a synthetic tetrapeptide amide, a sequence derived from the C-terminus of the amyloid beta peptide. This compound serves as a crucial biochemical tool and a key intermediate in peptide research and development. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for studying protein-protein interactions, enzyme kinetics, and as a building block for more complex peptide constructs.

Application

• Biochemical Research: Used as a standard, substrate, or inhibitor in enzymatic assays and studies related to amyloidogenesis and neurodegenerative disease pathways.
• Pharmaceutical Intermediates: Serves as a key synthetic fragment for the development of novel therapeutic peptides targeting neurological conditions.
• Protease Substrate: Acts as a specific substrate for studying the activity and inhibition of various proteases, including those implicated in Alzheimer's disease.
• Peptide Library Synthesis: Employed as a core structure or building block in the combinatorial synthesis of peptide libraries for drug discovery screening.
• Antibody Production: Can be used as a hapten to generate specific antibodies for immunoassays and diagnostic research.
• Academic & Institutional Research: Fundamental tool in university and institutional labs for teaching and investigating peptide chemistry and biochemistry.

Basic Information

Product Name	Arg-Gly-Phe-Phe-NH2
CAS No.	34367-74-3
Molecular Formula	C32H44N10O5
Molecular Weight	648.77 g/mol
Synonyms	H-Arg-Gly-Phe-Phe-NH2; Amyloid β-Protein (33-36) amide; Aβ(33-36) amide; L-Arginylglycyl-L-phenylalanyl-L-phenylalaninamide; R-G-F-F-NH2; Arg-Gly-Phe-Phe Amide; Tetrapeptide Amide R-G-F-F-NH2; ARA-400
EINECS	Contact for details

Quality Control

Our Arg-Gly-Phe-Phe-NH2 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure sequence integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Composition	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content (N)	≥ 70.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.