Description

Thyrotropin-Releasing Hormone, 1-Me- CAS NO 34367-55-0 is a synthetic, modified analog of the endogenous thyrotropin-releasing hormone (TRH). This compound is of significant value in biochemical and pharmaceutical research due to its enhanced metabolic stability compared to the native peptide. It is primarily required by research institutions, pharmaceutical development laboratories, and diagnostic manufacturers for use in neuroendocrine studies, receptor binding assays, and as a reference standard.

Application

• Neuroendocrine Research: Used as a stable analog to study the regulation of thyroid-stimulating hormone (TSH) and prolactin secretion.
• Pharmacological Studies: Employed in receptor characterization and binding affinity assays for TRH receptors in the central nervous system.
• Diagnostic Development: Serves as a critical reference standard and calibrator in the development of immunoassays for hormonal analysis.
• Peptide Chemistry: Utilized as a building block or model compound in studies focusing on peptide modification and stability.
• Neuroscience Research: Applied in investigations of TRH's neuromodulatory and potential neuroprotective effects.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, 1-Me- CAS NO 34367-55-0
CAS No.	34367-55-0
Molecular Formula	C16H23N6O4
Molecular Weight	363.39 g/mol
Synonyms	1-Methyl-TRH; 1-Methylthyrotropin-Releasing Hormone; 1-Me-TRH; L-Pyroglutamyl-L-histidyl-L-prolinamide, 1-Methyl-; 1-Methyl-L-pyroglutamyl-L-histidyl-L-prolinamide; Protirelin, 1-Methyl-; TRH, 1-Methyl-; (S)-5-Oxo-1-((S)-1-((S)-2-aminopropanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamide (alternative representation)
EINECS	Contact for details

Quality Control

Our Thyrotropin-Releasing Hormone, 1-Me- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-purity research standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.