Description

4-(2-Aminoethyl)Benzenesulfonylfluoride is a specialized organosulfur compound featuring a reactive sulfonyl fluoride group and a primary amine functionality. This dual reactivity makes it a valuable key synthetic intermediate and a versatile building block for the creation of more complex molecules. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of protease inhibitors, bioconjugation probes, and advanced material science applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of serine protease inhibitors and other bioactive molecules.
• Bioconjugation & Chemical Biology: Used as a reactive handle for labeling proteins, peptides, and other biomolecules due to its amine-reactive and sulfonyl fluoride groups.
• Proteomics Research: Serves as a key component in activity-based probes (ABPs) for studying enzyme function and mechanism.
• Material Science: Employed in the surface functionalization of polymers and nanoparticles to introduce amine or sulfonamide linkages.
• Organic Synthesis: Acts as a versatile building block for constructing sulfonamide-based compounds and heterocycles.
• Library Synthesis: Used in combinatorial chemistry for generating diverse compound libraries for drug discovery screening.

Basic Information

Product Name	4-(2-Aminoethyl)Benzenesulfonylfluoride
CAS No.	34284-75-8
Molecular Formula	C8H10FNO2S
Molecular Weight	203.23 g/mol
Synonyms	AEBSF; 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride; Pefabloc SC; 2-Aminoethylbenzenesulfonyl fluoride; (2-Aminoethyl)benzenesulfonyl fluoride; 4-Aminoethylbenzenesulfonyl fluoride; Benzenesulfonyl fluoride, 4-(2-aminoethyl)-; EINECS 251-934-7
EINECS	251-934-7

Quality Control

Our 4-(2-Aminoethyl)Benzenesulfonylfluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.