Description

Angiotensin I/II (5-8) is a bioactive peptide fragment derived from the angiotensinogen sequence, specifically encompassing residues 5 through 8. This compound is a critical intermediate and reference standard in cardiovascular and renal system research, serving as a key tool for studying the renin-angiotensin system (RAS). It is essential for pharmaceutical R&D, biochemical assay development, and academic research focused on hypertension, heart failure, and related metabolic disorders. The product is supplied with full analytical documentation to ensure research integrity and reproducibility.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, MS) in drug development and quality control.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies of angiotensin-converting enzyme (ACE) and other proteases within the RAS pathway.
• Cell Culture & In Vitro Assays: Applied in receptor binding studies and cellular signaling experiments to investigate mechanisms of blood pressure regulation.
• Antibody Production & Immunoassays: Acts as a hapten for generating specific antibodies used in ELISA, RIA, and other diagnostic immunoassays.
• Peptide Synthesis & Modification: Utilized as a building block or template for the synthesis of novel peptide analogs and drug candidates.
• Academic & Clinical Research: Fundamental tool for investigating the pathophysiology of cardiovascular diseases, diabetes, and kidney disorders.

Basic Information

Product Name	Angiotensin I/II (5-8)
CAS No.	34233-50-6
Molecular Formula	C₂₃H₃₈N₈O₆
Molecular Weight	522.60 g/mol
Synonyms	Angiotensin (5-8); Ile-His-Pro-Phe; IHPF; L-Isoleucyl-L-histidyl-L-prolyl-L-phenylalanine; H-Ile-His-Pro-Phe-OH; Angiotensin I/II Fragment 5-8; Angiotensinogen (5-8)
EINECS	Contact for details

Quality Control

Our Angiotensin I/II (5-8) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and compliance documentation. A detailed Certificate of Analysis (COA) is supplied with every shipment, ensuring it meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Peptide Content (AAA)	≥ 80.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.