Description

Z-Gln-Osu is a protected glutamine derivative, specifically Nα-benzyloxycarbonyl-L-glutamine N-hydroxysuccinimide ester, widely used as a key building block in peptide synthesis. Its primary value lies in its role as an activated ester, which facilitates efficient and selective amide bond formation under mild conditions, crucial for constructing complex peptide sequences. This high-purity reagent is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries engaged in the development of peptide-based therapeutics, diagnostics, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the controlled incorporation of glutamine residues into growing peptide chains, minimizing side reactions like racemization.
• Solution-Phase Peptide Synthesis: Used in classical solution-phase methods for the synthesis of short peptides and peptide fragments.
• Peptide Drug Intermediate Production: Serves as a key raw material in the manufacturing of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation and Labeling: Facilitates the attachment of peptides to other molecules, such as proteins, dyes, or solid supports, for diagnostic and research applications.
• Research & Development: Indispensable in academic and industrial R&D labs for exploring new peptide structures, studying protein-protein interactions, and developing novel bioactive compounds.
• Custom Peptide Service Providers: A staple chemical for companies offering bespoke peptide synthesis services to the global research community.

Basic Information

Product Name	Z-Gln-Osu
CAS No.	34078-85-8
Molecular Formula	C₁₇H₁₉N₃O₇
Molecular Weight	377.35 g/mol
Synonyms	Nα-Cbz-L-glutamine N-hydroxysuccinimide ester; Z-L-Glutamine N-hydroxysuccinimide ester; N-(Benzyloxycarbonyl)-L-glutamine N-succinimidyl ester; N-Carbobenzoxy-L-glutamine N-hydroxysuccinimide ester; Cbz-Gln-OSu; Z-Glutamine-OSu; Nα-Z-L-glutamine acid N-hydroxysuccinimide ester; Benzyl N-[(2S)-4-carbamoyl-1-oxo-1-[(2,5-dioxopyrrolidin-1-yl)oxy]butan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Z-Gln-Osu CAS NO 34078-85-8 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing batch-specific results. Our quality commitment ensures material suitability for demanding applications in cGMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.