Description

4-Chloro-D-Phenylalanine Methyl Ester Hydrochloride is a chiral, halogenated amino acid derivative primarily used as a critical synthetic intermediate in pharmaceutical research and development. This compound matters for its role in constructing complex molecules, particularly in the synthesis of peptide-based drugs and enzyme inhibitors. It is needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for applications ranging from medicinal chemistry to process scale-up.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel therapeutic agents, particularly those targeting neurological and metabolic pathways.
• Peptidomimetic Research: Used to incorporate chlorinated phenylalanine analogs into peptide chains to study structure-activity relationships and enhance metabolic stability.
• Enzyme Inhibition Studies: Serves as a precursor for developing selective inhibitors of enzymes like tryptophan hydroxylase, relevant in serotonin research.
• Chiral Synthesis: Provides a source of D-configuration chirality for the asymmetric synthesis of more complex, biologically active molecules.
• Chemical Biology Probes: Utilized in the creation of labeled or modified amino acids for probing biological mechanisms and protein interactions.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-Chloro-D-Phenylalanine Methyl Ester Hydrochloride
CAS No.	33965-47-8
Molecular Formula	C10H13ClNO2 • HCl
Molecular Weight	264.13 g/mol (Free base: 227.67)
Synonyms	Methyl (2R)-2-amino-3-(4-chlorophenyl)propanoate hydrochloride; D-4-Chlorophenylalanine methyl ester HCl; (R)-Methyl 2-amino-3-(4-chlorophenyl)propanoate hydrochloride; Methyl D-p-chlorophenylalaninate hydrochloride; PCPA methyl ester hydrochloride; 4-Cl-D-Phe-OMe • HCl; (R)-2-Amino-3-(4-chlorophenyl)propionic acid methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Chloro-D-Phenylalanine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and development applications. Certificates of Analysis (COA) providing detailed specifications for identity, purity, and impurities are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.