Description

(2S)-1-[(2S)-2-Amino-3-(3H-Imidazol-4-Yl)Propanoyl]Pyrrolidine-2-Carboxamide CAS NO 33605-69-5 is a high-purity, non-natural amino acid derivative featuring a proline-amide backbone linked to a histidine-like side chain. This compound matters as a critical chiral building block and intermediate for advanced pharmaceutical research and peptide synthesis, offering precise stereochemical control. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for developing novel therapeutic agents, particularly protease inhibitors and other bioactive peptides.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel drug candidates, especially those targeting enzymatic pathways.
• Peptide Synthesis: Used as a specialized amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce constrained proline and imidazole functionalities.
• Protease Inhibitor Research: Acts as a core scaffold or precursor in the development of inhibitors for various proteases due to its structural mimicry of transition states.
• Bioconjugation & Labeling: The reactive amine and amide groups provide sites for chemical modification, labeling, or linker attachment in bioconjugate chemistry.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and protein-protein interactions.
• Academic & Institutional Research: Employed in university and research institute laboratories for fundamental studies in medicinal chemistry and peptide science.

Basic Information

Product Name	(2S)-1-[(2S)-2-Amino-3-(3H-Imidazol-4-Yl)Propanoyl]Pyrrolidine-2-Carboxamide
CAS No.	33605-69-5
Molecular Formula	C11H17N5O2
Molecular Weight	251.29 g/mol
Synonyms	L-Histidyl-L-prolinamide; (S)-1-((S)-2-Amino-3-(1H-imidazol-4-yl)propanoyl)pyrrolidine-2-carboxamide; Histidyl-Prolinamide; H-His-Pro-NH2; CAS 33605-69-5; 1-[(2S)-2-Amino-3-(1H-imidazol-4-yl)propanoyl]-L-prolinamide; L-Histidyl-L-proline amide
EINECS	Contact for details

Quality Control

Our (2S)-1-[(2S)-2-Amino-3-(3H-Imidazol-4-Yl)Propanoyl]Pyrrolidine-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.