Description

Ethyl 6-Methyl-4-Phenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. Industrial and research chemists in the pharmaceutical, agrochemical, and fine chemical sectors require this precise chemical for its role in creating compounds with potential biological activity.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of dihydropyrimidinone (DHPM) derivatives, which are a core scaffold for drugs with diverse therapeutic applications.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its heterocyclic structure for targeted biological activity.
• Catalyst & Ligand Synthesis: Serves as a starting material for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Investigated as a building block for organic electronic materials and specialty polymers due to its conjugated system.
• Academic & R&D: Essential for medicinal chemistry programs and methodological studies in multicomponent reactions, such as the Biginelli reaction.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the bespoke production of client-specific target molecules.

Basic Information

Product Name	Ethyl 6-Methyl-4-Phenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	33458-26-3
Molecular Formula	C14H16N2O2S
Molecular Weight	276.35 g/mol
Synonyms	Ethyl 4-Phenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 5-Carbethoxy-6-methyl-4-phenyl-3,4-dihydro-2(1H)-pyrimidinethione; 4-Phenyl-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acid Ethyl Ester; Biginelli Reaction Product; DHPM Derivative; 2-Thioxodihydropyrimidine-5-carboxylate; 3,4-Dihydropyrimidin-2(1H)-thione Derivative
EINECS	Contact for details

Quality Control

Our Ethyl 6-Methyl-4-Phenyl-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to moisture and atmospheric oxygen. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.