Description

Antamanide, 1-De-L-Alanine-3A-Endo-L-Valine- is a synthetic cyclic decapeptide analog derived from the natural toxin amanitin. This compound is of significant interest in biochemical and pharmacological research due to its specific interaction with RNA polymerase II, serving as a valuable tool for studying transcription inhibition. It is primarily utilized by research institutions and pharmaceutical development laboratories focused on molecular biology, toxicology, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a selective inhibitor of RNA polymerase II in mechanistic studies of eukaryotic transcription.
• Pharmacological Tool Compound: Employed in vitro to investigate cellular apoptosis pathways and the effects of transcription blockade.
• Toxicology Studies: Serves as a reference standard or model compound for studying the mechanisms of amatoxin poisoning.
• Drug Discovery: Acts as a lead compound or structural template in the design of novel transcription-targeting therapeutics.
• Academic Research: Utilized in university and institutional labs for advanced studies in molecular biology and cell signaling.
• Peptide Chemistry Reference: Provides a benchmark for synthetic peptide chemistry due to its complex cyclic structure.

Basic Information

Product Name	Antamanide, 1-De-L-Alanine-3A-Endo-L-Valine-
CAS No.	33426-38-9
Molecular Formula	C54H78N10O12
Molecular Weight	1043.26 g/mol
Synonyms	1-De-L-Alanine-3A-Endo-L-Valine-Antamanide; Antamanide, 1-de-L-alanine-3A-endo-L-valine-; Cyclo[L-Val(1)-L-Ala(2)-L-Pro(3)-L-Pro(4)-L-Phe(5)-L-Phe(6)-L-Pro(7)-L-Pro(8)-L-Phe(9)-L-Phe(10)] (cyclic decapeptide analog); Antamanide derivative; RNA polymerase II inhibitor (amatoxin analog); [1-De-Ala,3A-Endo-Val]-Antamanide
EINECS	Contact for details

Quality Control

Our Antamanide, 1-De-L-Alanine-3A-Endo-L-Valine- is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals, ensuring reliable performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Keep the container tightly sealed after each use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.