Description

3''-Phosphoryldihydrostreptomycin is a chemically modified derivative of the classic aminoglycoside antibiotic, dihydrostreptomycin. This compound is of significant interest in biochemical and pharmaceutical research, particularly for its role as a key intermediate in the synthesis of novel antibiotic conjugates and for studying bacterial resistance mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing advanced antimicrobial agents and molecular probes.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation aminoglycoside antibiotics and targeted drug conjugates.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate phosphorylation pathways and bacterial ribosome function.
• Antimicrobial Mechanism Studies: Employed in research to understand and combat bacterial resistance to streptomycin-class antibiotics.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Probe Development: Utilized in the creation of labeled probes for studying drug-target interactions within biological systems.

Basic Information

Product Name	3''-Phosphoryldihydrostreptomycin
CAS No.	33419-36-2
Molecular Formula	C21H41N7O17P
Molecular Weight	694.57 g/mol
Synonyms	Dihydrostreptomycin 3''-phosphate; Streptomycin, dihydro-, 3''-(dihydrogen phosphate); Dihydrostreptomycin phosphate (3''-isomer); 3''-O-Phosphonodihydrostreptomycin; 3''-Phosphodihydrostreptomycin; DHSM-3''-P; NSC 113926
EINECS	Contact for details

Quality Control

Our 3''-Phosphoryldihydrostreptomycin is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 1.0 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.