Description

D-Aminolevulinicacidmethylesterhydrochloride is a hydrochloride salt derivative of 5-aminolevulinic acid methyl ester, a key biochemical precursor in the heme biosynthesis pathway. This compound is valued for its role as a prodrug in photodynamic therapy and diagnostic applications, where it is metabolized to produce protoporphyrin IX, a potent photosensitizer. It is primarily required by pharmaceutical manufacturers, research institutions, and clinical laboratories developing and producing advanced therapeutic and diagnostic agents for oncology and dermatology.

Application

• Photodynamic Therapy (PDT): Serves as a prodrug for the targeted generation of protoporphyrin IX (PpIX) in cancer cells, enabling light-activated tumor destruction.
• Photodynamic Diagnosis (PDD): Used in fluorescence-guided surgery and tumor margin delineation due to the selective accumulation and fluorescence of its metabolite, PpIX.
• Dermatological Treatments: Applied topically for the treatment of actinic keratosis, basal cell carcinoma, and other non-melanoma skin cancers.
• Biochemical Research: A critical reagent in studies of porphyrin metabolism, heme biosynthesis, and cellular mechanisms of photosensitization.
• Pharmaceutical Intermediates: Used in the synthesis of more complex porphyrin-based compounds and active pharmaceutical ingredients (APIs).
• Veterinary Medicine: Investigated for use in PDT applications for companion animals.

Basic Information

Product Name	D-Aminolevulinicacidmethylesterhydrochloride
CAS No.	33320-16-0
Molecular Formula	C6H12ClNO3
Molecular Weight	181.62 g/mol
Synonyms	5-Aminolevulinic Acid Methyl Ester Hydrochloride; Methyl 5-Aminolevulinate Hydrochloride; ALA Methyl Ester HCl; 5-ALA Methyl Ester Hydrochloride; Methyl Aminolevulinate HCl; 5-Amino-4-oxopentanoic Acid Methyl Ester Hydrochloride; δ-Aminolevulinic Acid Methyl Ester Hydrochloride; MAL HCl
EINECS	Contact for details

Quality Control

Our D-Aminolevulinicacidmethylesterhydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and heavy metals to ensure compliance with high-grade standards. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.