Description

Boc-Ala-Pro-Oh CAS NO 33300-72-0 is a protected dipeptide building block, specifically N-(tert-Butoxycarbonyl)-L-alanyl-L-proline, widely utilized in solid-phase peptide synthesis (SPPS). This compound is critical for the controlled elongation of peptide chains, offering excellent orthogonality for the selective deprotection of the N-terminal Boc group under acidic conditions. It is an essential raw material for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of complex therapeutic peptides and peptide-based drug candidates.
• Solid-Phase Peptide Synthesis (SPPS): Used in Boc-chemistry strategies for the sequential assembly of peptides on resin supports.
• Biochemical Research: Employed in the study of enzyme substrates, inhibitors, and the structure-activity relationships (SAR) of peptides.
• Peptidomimetic Development: Serves as a scaffold for creating modified peptides with enhanced stability and bioavailability.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening.
• Academic & Industrial R&D: Fundamental reagent for universities, contract research organizations (CROs), and biotech companies.

Basic Information

Product Name	Boc-Ala-Pro-Oh
CAS No.	33300-72-0
Molecular Formula	C14H24N2O5
Molecular Weight	300.35 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-alanyl-L-proline; Boc-L-alanyl-L-proline; Boc-Ala-Pro-OH; (S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)pyrrolidine-1-carboxylic acid; BOC-ALA-PRO; tert-Butyloxycarbonyl-alanyl-proline; N-Boc-L-alanyl-L-proline; Nα-Boc-L-alanyl-L-proline
EINECS	Contact for details

Quality Control

Our Boc-Ala-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	-70° to -80° (c=1, AcOH)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.