Description

5-Bromo-2,4-Bis(trimethylsilyloxy)pyrimidine is a key organosilicon-protected pyrimidine derivative, primarily utilized as a versatile synthetic intermediate in advanced organic synthesis. Its value lies in the strategic protection of reactive hydroxyl groups, enabling precise and efficient multi-step chemical transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of nucleoside analogs, active pharmaceutical ingredients (APIs), and complex heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides with specific modes of action.
• Organic Synthesis Reagent: Serves as a protected synthon for the controlled functionalization of the pyrimidine ring system in complex molecule assembly.
• Material Science Research: Employed in the development of organic semiconductors and specialty polymers containing heterocyclic units.
• Nucleic Acid Chemistry: Facilitates the modification of nucleosides and nucleotides for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects requiring high-purity, specialty intermediates.

Basic Information

Product Name	5-Bromo-2,4-Bis(trimethylsilyloxy)pyrimidine
CAS No.	33282-64-3
Molecular Formula	C10H19BrN2O2Si2
Molecular Weight	367.35 g/mol
Synonyms	5-Bromo-2,4-bis[(trimethylsilyl)oxy]pyrimidine; 2,4-Bis(trimethylsilyloxy)-5-bromopyrimidine; 5-Bromo-2,4-pyrimidinediol bis(trimethylsilyl) ether; 5-Bromopyrimidine-2,4-diol bis(trimethylsilyl) ether; 5-Bromo-2,4-di-O-(trimethylsilyl)pyrimidine; 5-Br-2,4-diOTMS-pyrimidine; Pyrimidine, 5-bromo-2,4-bis[(trimethylsilyl)oxy]- (9CI)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,4-Bis(trimethylsilyloxy)pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and production quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.