Description

Pglu-L-His-L-Met-Nh2 is a synthetic tripeptide derivative, specifically a pyroglutamyl-histidyl-methionine amide. This compound is of significant interest in advanced biochemical research and pharmaceutical development due to its unique peptide backbone and functional side chains. It serves as a critical intermediate or reference standard for researchers in medicinal chemistry, peptide synthesis, and metabolic studies.

Application

• Pharmaceutical Intermediate: Used in the research and development of novel therapeutic peptides and peptidomimetics.
• Biochemical Research: Acts as a reference standard or substrate in enzymatic studies and metabolic pathway analysis.
• Medicinal Chemistry: Serves as a building block for structure-activity relationship (SAR) studies to optimize biological activity.
• Cosmeceutical Research: Investigated for potential applications in advanced skincare formulations targeting specific biological pathways.
• Academic Research: Utilized in university and institutional labs for fundamental studies in peptide science and bioorganic chemistry.

Basic Information

Product Name	Pglu-L-His-L-Met-Nh2
CAS No.	33217-49-1
Molecular Formula	C17H25N7O4S
Molecular Weight	423.49 g/mol
Synonyms	Pyroglutamyl-histidyl-methionine amide; L-Pyroglutamyl-L-histidyl-L-methioninamide; 5-Oxo-L-prolyl-L-histidyl-L-methioninamide; pGlu-His-Met-NH2; TRH-related peptide; Thyrotropin-releasing hormone analog; pGlu-His-Met amide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Pglu-L-His-L-Met-Nh2 is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment and MS for identity confirmation. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, and our quality system supports compliance with cGMP standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.