Description

Pglu-L-His-L-Thr-Nh2 CAS NO 33217-48-0 is a synthetic tripeptide derivative, specifically pyroglutamyl-histidyl-threoninamide. This compound is of significant interest in biochemical research and pharmaceutical development due to its role as a peptide intermediate and potential biological activity. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in peptide synthesis, drug discovery, and metabolic pathway studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of more complex therapeutic peptides and peptidomimetics.
• Biochemical Research: Used as a reference standard or substrate in enzymatic studies and receptor binding assays.
• Drug Discovery: Investigated for potential biological activities in metabolic and endocrine research programs.
• Peptide Library Synthesis: Employed in combinatorial chemistry for creating diverse peptide libraries for screening.
• Academic Research: Utilized in university and institutional labs for studying peptide structure-activity relationships (SAR).

Basic Information

Product Name	Pglu-L-His-L-Thr-Nh2
CAS No.	33217-48-0
Molecular Formula	C17H25N7O5
Molecular Weight	407.43 g/mol
Synonyms	Pyroglutamyl-histidyl-threoninamide; Pyroglutamyl-L-histidyl-L-threoninamide; pGlu-His-Thr-NH2; L-Pyroglutamyl-L-histidyl-L-threoninamide; 5-Oxo-L-prolyl-L-histidyl-L-threoninamide; 5-Oxo-Pro-His-Thr-NH2; (S)-2-(2-((S)-1-Hydroxy-3-((S)-1H-imidazol-5-yl)propan-2-ylamino)-2-oxoethyl)-5-oxopyrrolidine-1-carboxamide (IUPAC); TRH Fragment (1-3) amide
EINECS	Contact for details

Quality Control

Our Pglu-L-His-L-Thr-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC are provided with every shipment to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.