Description

4-Azido-L-Phenylalanine is a non-canonical amino acid derivative featuring a reactive azido group, making it a critical building block for bioorthogonal chemistry. Its primary value lies in enabling site-specific protein labeling and modification via click chemistry reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and manufacturers in bioconjugation, chemical biology, and pharmaceutical development, where precise biomolecule engineering is required.

Application

• Site-Specific Protein Labeling: Incorporation into proteins for subsequent conjugation with fluorescent dyes, biotin, or other probes via click chemistry.
• Chemical Biology Probes: Synthesis of activity-based probes for studying enzyme function and protein-protein interactions in living systems.
• Antibody-Drug Conjugate (ADC) Development: Enabling the generation of homogeneous, stable ADCs with defined drug-to-antibody ratios (DAR).
• Materials Science: Functionalization of surfaces, polymers, and nanomaterials with bioactive ligands for biosensor and diagnostic applications.
• Peptide & Protein Engineering: Creating novel peptide therapeutics and engineered proteins with tailored properties and functionalities.
• Post-Translational Modification Mimetics: Studying and mimicking natural protein modifications in research settings.

Basic Information

Product Name	4-Azido-L-Phenylalanine
CAS No.	33173-53-4
Molecular Formula	C9H10N4O2
Molecular Weight	206.20 g/mol
Synonyms	p-Azido-L-phenylalanine; L-4-Azidophenylalanine; (2S)-2-Amino-3-(4-azidophenyl)propanoic acid; Fmoc-4-Azido-L-Phenylalanine (protected form); Azido-Phe; Azi; 4-Azido-DL-Phenylalanine (racemic mixture); AzPhe
EINECS	Contact for details

Quality Control

Our 4-Azido-L-Phenylalanine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.