Description

Poly(Glutamyl-Tyrosyl-Alanyl-Glycine) is a synthetic tetrapeptide sequence composed of the amino acids glutamic acid, tyrosine, alanine, and glycine. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a model peptide substrate for studying enzyme kinetics and proteolytic activity. It serves as a critical intermediate and reference standard for developers in the life sciences, particularly in enzymology and diagnostic assay development. The product is supplied as a high-purity material to ensure reliable and reproducible experimental results.

Application

• Enzymology Research: Used as a specific substrate for studying the activity and inhibition of proteolytic enzymes like chymotrypsin and other serine proteases.
• Biochemical Assay Development: Serves as a key component in the development and validation of colorimetric or fluorometric enzyme activity assays.
• Pharmaceutical R&D: Acts as a model compound for investigating peptide stability, metabolism, and drug-enzyme interactions during preclinical studies.
• Diagnostic Reagents: Employed in the manufacturing of calibration standards and controls for clinical diagnostic kits targeting specific protease levels.
• Academic Research: Provides a well-defined peptide sequence for teaching and fundamental research in biochemistry and molecular biology laboratories.
• Peptide Synthesis Reference: Used as a benchmark for purity and analytical method development in solid-phase and solution-phase peptide synthesis.

Basic Information

Product Name	Poly(Glutamyl-Tyrosyl-Alanyl-Glycine)
CAS No.	33135-70-5
Molecular Formula	C22H30N6O9
Molecular Weight	522.51 g/mol
Synonyms	Glu-Tyr-Ala-Gly; Glutamyl-Tyrosyl-Alanyl-Glycine; EYAG; Poly(Glu-Tyr-Ala-Gly); L-Glutamyl-L-tyrosyl-L-alanylglycine; Tetrapeptide EYAG; H-Glu-Tyr-Ala-Gly-OH; (4S)-4-[[(2S)-2-[[(2S)-2-Amino-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoic acid
EINECS	Contact for details

Quality Control

Our Poly(Glutamyl-Tyrosyl-Alanyl-Glycine) is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing including HPLC for purity assessment, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.