Description

Tobramycin CAS NO 32986-56-4 is a potent aminoglycoside antibiotic derived from *Streptomyces tenebrarius*. It is a critical active pharmaceutical ingredient (API) valued for its broad-spectrum bactericidal activity, particularly against Gram-negative pathogens. This compound is essential for manufacturers in the pharmaceutical industry, primarily for the formulation of injectable solutions, ophthalmic preparations, and inhalation therapies used to treat serious infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable antibiotic formulations.
• Ophthalmic Solutions: Formulation of eye drops and ointments for treating bacterial conjunctivitis and keratitis.
• Inhalation Therapy: Key component in nebulizer solutions for managing chronic pulmonary infections in cystic fibrosis patients.
• Veterinary Medicine: Used in topical and injectable veterinary products for bacterial infections in animals.
• Research & Development: Serves as a reference standard and building block in microbiological and pharmacological research.
• Combination Therapies: Used in synergistic combination with other antibiotics for enhanced efficacy against resistant strains.

Basic Information

Product Name	Tobramycin
CAS No.	32986-56-4
Molecular Formula	C18H37N5O9
Molecular Weight	467.52 g/mol
Synonyms	Tobramycin; Nebcin; Tobra; TOBI; Obramycin; 3'-Deoxykanamycin B; (2S,3R,4S,5S,6R)-4-Amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R,4S,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol
EINECS	251-321-0

Quality Control

Our Tobramycin is produced and tested to meet stringent pharmacopeial standards, including USP and EP monographs. Each batch undergoes comprehensive analytical testing for identity, potency, and purity, with strict limits on related substances and residual solvents. A Certificate of Analysis (COA) documenting compliance with specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature of 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	95.0% - 102.0% (on anhydrous basis)
pH (1% solution)	9.0 - 11.0
Water (Karl Fischer)	≤ 8.0%
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%; Total impurities ≤ 5.0%
Bacterial Endotoxins	< 2.0 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.