Description

trans-4-Hydroxy-L-Proline Hydrochloride is a high-purity, non-proteinogenic amino acid derivative, essential for advanced biochemical synthesis and research. This compound serves as a critical chiral building block and precursor in the development of complex pharmaceutical actives and fine chemicals. It is primarily utilized by research institutions, pharmaceutical development labs, and manufacturers of high-value peptides and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of collagenase inhibitors, antiviral agents, and other therapeutic compounds.
• Peptide Synthesis: Used as a protected or unprotected amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce hydroxyproline residues.
• Biochemical Research: Employed in enzymatic studies, metabolic pathway analysis, and as a standard in analytical chromatography for amino acid analysis.
• Cell Culture Media: A component in specialized cell culture formulations, particularly for collagen-producing cell lines.
• Cosmetic & Nutraceutical Ingredients: A precursor in the manufacture of collagen peptides and other bioactive ingredients for skincare and dietary supplements.
• Asymmetric Catalysis: Utilized as a chiral ligand or auxiliary in asymmetric synthesis to induce stereoselectivity.

Basic Information

Product Name	trans-4-Hydroxy-L-Proline Hydrochloride
CAS No.	32968-78-8
Molecular Formula	C₅H₉NO₃·HCl
Molecular Weight	167.59 g/mol
Synonyms	(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride; L-4-Hydroxyproline hydrochloride; (4R)-4-Hydroxy-L-proline hydrochloride; Hyp-OH·HCl; 4-Hydroxy-L-proline monohydrochloride; trans-Hydroxyproline hydrochloride; L-Hydroxyproline HCl
EINECS	Contact for details

Quality Control

Our trans-4-Hydroxy-L-Proline Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and tests for residual solvents and heavy metals. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥98.5%
Optical Rotation [α]²⁰D	-70° to -76° (c=1 in H₂O)
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.