Description

Z-Gly-Gly-Osu CAS NO 32943-08-1 is a protected dipeptide derivative, specifically the N-benzyloxycarbonyl (Z) protected form of glycylglycine activated with an N-hydroxysuccinimide (Osu) ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and controlled elongation of peptide chains. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers involved in producing custom peptides, peptide mimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester, it is a key reagent for the controlled coupling of the Gly-Gly dipeptide unit, minimizing racemization.
• Pharmaceutical Intermediate: Used in the research and development of therapeutic peptides targeting metabolic disorders, neurological conditions, and hormonal therapies.
• Bioconjugation: Serves as a linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or carriers in drug delivery system development.
• Biochemical Research: Employed in enzymology studies as a substrate analog or inhibitor for proteases like dipeptidyl peptidases (DPP-IV).
• Production of Longer Peptide Fragments: Acts as a pre-formed, protected dipeptide block for the efficient synthesis of complex polypeptides and proteins.
• Fine Chemical Synthesis: Utilized in the custom synthesis of peptide-based catalysts, materials, and specialty chemicals.

Basic Information

Product Name	Z-Gly-Gly-Osu
CAS No.	32943-08-1
Molecular Formula	C16H19N3O7
Molecular Weight	365.34 g/mol
Synonyms	Nα-Benzyloxycarbonyl-glycyl-glycine N-hydroxysuccinimide ester; Z-Gly-Gly-OSu; Cbz-Gly-Gly-OSu; N-Cbz-glycylglycine N-succinimidyl ester; Benzyloxycarbonyl-glycyl-glycine N-hydroxysuccinimide ester; Glycine, N-[(benzyloxy)carbonyl]glycyl-, 2,5-dioxo-1-pyrrolidinyl ester; NSC 334681; (2,5-Dioxopyrrolidin-1-yl) 2-[[2-[(benzyloxy)carbonylamino]acetyl]amino]acetate
EINECS	Contact for details

Quality Control

Our Z-Gly-Gly-Osu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide Certificates of Analysis (COA) with detailed specifications to ensure traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.